Human circular rna database

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August undefined, 2024

Web10 Apr 2024 · Circular RNA (or circRNA) is a type of single-stranded covalently closed circular RNA molecule and play important roles in diverse biological pathways. A … WebKnockdown of circPHC3 inhibited cell death and apoptosis in human BMECs treated with OGD. Mechanistically, circPHC3 acted as miR-455-5p sponge to activate TRAF3 to promote cell death and apoptosis in human BMECs after OGD. Conclusion: In short, circPHC3 promotes cell death and apoptosis in ischemic stroke in vitro model, which might be a …

Long Non-coding Rna Database - Encyclopedia Information

Web13 Apr 2024 · Novel RNA constructs to amplify RNA expression (e.g., self-amplifying RNA, circular RNA), modify translation (e.g., miRNA, siRNA), and gene editing (Cas9 mRNA, single guide RNA [sgRNA]) hold promise for next-generation cancer immunotherapy. Targeted delivery vehicles, including lipid and polymer nanoparticles, cell or extracellular … Web8 Mar 2024 · Circular RNAs (circRNAs) are an abundant class of covalently closed endogenous RNA molecules generated by back-splicing of pre-mRNAs. Recent … html input file accept only one file

Novel insights into circular RNAs in clinical application of …

Web6 Jun 2024 · Circular RNAs (circRNAs) are a family of regulatory RNAs with loop structures which implies they do not have 5`Caps and 3` Poly (A) tails [ 1 ]. Although a great number of circRNAs have been identified, their functions are still largely unknown. CircRNAs are generally considered noncoding RNAs with various biological functions. Web4 Apr 2024 · INTRODUCTION. Mitochondria and their 16.5-kb circular genomes (mtDNA) undergo constant turnover in arrested primary oocytes for decades in humans (1, 2).Frequent DNA replication and lack of efficient DNA repair mechanism in the mitochondrion contribute to a mutation rate that is ∼10-fold higher than that of the … WebCircular RNAs (circRNAs) are a class of abundant and conserved RNAs in animals and plants [1-3] . Most circRNAs are produced from a special type of alternative splicing known as back-splicing, and are predominantly localized in cytoplasm [3-5] . However, the general function of circRNA in vivo is still an open question. html input field date

Circular RNAs and their role in renal cell carcinoma: a current ...

Circular RNA Is Expressed across the Eukaryotic Tree of Life

Webcircular RNA of interest and update the database continually. circRNADb will be built to be a biological information platform for circRNA molecules and related biological functions in … Web17 Jun 2024 · We identified 13 pre-existing circRNA databases 23, and most (99%) of the RNA Atlas circRNAs were annotated in at least one circRNA database (only 446 … hocus pocus hd gameWeb3 Jan 2024 · Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, … html input fields side by side

"Web3 Dec 2024 · NeuroCirc is an integrative web-based resource of circRNA expression in the human brain. Circular RNA Interactome enables the prediction and mapping of binding … " - Human circular rna database

Human circular rna database

The RNA Atlas expands the catalog of human non-coding RNAs

Web14 Oct 2024 · Circular RNAs (circRNAs), a class of covalently closed RNA molecules formed via back-splicing (BS) or lariat precursors, are involved in various biological processes and pathogenesis by fine-tuning the eukaryotic gene regulatory network ( Kristensen et al., 2024; Chen, 2024 ). Web10 Jul 2024 · Circular RNAs (circRNAs) are an emerging RNAs type differing from traditional linear RNAs. They are abundant in eukaryotic transcriptome and form covalently closed continuous loops, where the 3′ and 5′ ends presenting in an RNA molecule in a normal manner are joined jointly [ 1 ].

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Web15 Apr 2024 · The genome of SARS-CoV-2 coronavirus is made up of a single-stranded RNA fragment that can assume a specific second-ary structure, whose stability can influence the virus ability to reproduce. Recent studies have identified putative guanine quadruplex sequences in SARS-CoV-2 genome fragments that are involved in coding for … Web22 Nov 2024 · Unlike linear RNA, circular RNA (circRNA) is a group of non-coding RNA which forms a covalently closed continuous loop from exon circularization. ... Chen X, Han P, Zhou T, et al. circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations. Sci Rep 2016;6:34985. Zheng LL, Li JH, Wu J, et al. …

http://circbase.org/ Web1 day ago · Previous data have revealed that a circular RNA derived from the superoxide dismutase 2 mitochondrial (SOD2) gene (circ-SOD2) is overexpressed in HCC tumor tissues compared to adjacent normal liver tissues . SOD2 is a member of the iron/manganese superoxide dismutase that eliminates mitochondrial reactive oxygen species (ROS) and …

Web2 days ago · We developed a suite of methods called Lachesis to detect single-nucleotide DNA PZMs from bulk RNA sequencing (RNA-seq) data. We applied these methods to the final major release of the NIH Genotype-Tissue Expression (GTEx) project—a catalog of 17,382 samples derived from 948 donors across 54 diverse tissues and cell types—to … Web14 Apr 2024 · Circular RNAs (circRNAs), which are produced post-splicing of pre-mRNAs, are strongly linked to the emergence of several tumor types. The initial stage in conducting follow-up studies involves identifying circRNAs. Currently, animals are the primary target of most established circRNA recognition technologies. However, the sequence features of …

Web11 Oct 2016 · In this study we established a circRNA database, named as circRNADb, containing 32,914 human exonic circRNAs carefully selected from diversified sources. …

html input file accept pdf onlyWeb15 Jul 2024 · Circular RNAs (circRNAs), which are a class of endogenous RNA with covalently closed loops, play important roles in epigenetic regulation of gene expression at both the transcriptional and post-transcriptional level. Accumulating evidence demonstrated that numerous circRNAs were abnormally expressed in tumors and their dysregulation … html input file accept excel onlyWeb10 Dec 2013 · Circular RNAs are new players in regulation of post transcriptional gene expression. Animal genomes express many circular RNAs from diverse genomic … hocus pocus hd wallpaperWebHere, we assembled the metagenomic sequencing reads from 702 human fecal virome/phageome samples and analyzed 99 complete circular crAss-like phage genomes and 150 contigs ≥70 kb. In silico comparative genomics and taxonomic analysis enabled a classification scheme of crAss-like phages from human fecal microbiomes into four … html input field too wideWeb1 Apr 2024 · In the database, 2191 circRNAs and 168 lncRNAs contain at least one entire or partial IRES element. Among these transcripts, 1012 circRNAs contain an ORF longer than 300 nucleotides, and all the 168 lncRNAs contain at least two small ORFs (ranging from 60 to 300 nucleotides in length). html input file eventsWebRibonucleoproteins (RNPs) comprise one or more RNA and protein molecules that interact to form a stable complex, which commonly involves conformational changes in the more flexible RNA components. Here, we propose that Cas12a RNP assembly with its cognate CRISPR RNA (crRNA) guide instead proceeds primarily through Cas12a conformational … html input file attributesWebAntisense to the cerebellar degeneration-related protein 1 transcript (CDR1as) and the testis-specific circRNA, Sex-determining region Y(Sry) are the most representative miRNA sponges. 40,43,44 The exonic circRNAs of CDR1as and Sry have been shown to bind miRNAs without being degraded, making them excellent candidates for competing … hocus pocus her universe