WebApr 12, 2024 · Human adenovirus (HAdv) infects humans and causes a variety of respiratory and intestinal diseases. In children, it is highly infectious and infection with HAdv often leads to diseases such as acute respiratory disease (ARD), which includes upper respiratory tract infection, bronchitis and pneumonia ( Tsou et al., 2012; Foong Ng et al., … WebHuman adenovirus 1 (Ad) has been used extensively to derive replication-incompetent gene delivery vectors to correct genetic disorders and develop candidate vaccines for a …
Enhanced Tropism of Species B1 Adenoviral-Based Vectors for …
WebOur results indicate that human Ad3 and Ad7 cause marked pulmonary pathology, inducing similar host responses in the respiratory tract, thus validating the use of the mouse model for the study of early virus-host interactions during lung infection by adenoviruses of subspecies B1. Copyright 2003 Wiley-Liss, Inc. Publication types Evaluation Study WebJun 24, 2010 · We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and release of the endosomalytic protein VI during cell entry. Consequently, AdV remains trapped in the endosomal/lysosomal pathway rather than trafficking to the nucleus. ... B1, B2, C, and E, whereas species D and F are resistant ... on off museum
Frontiers Epidemiology and Genetic Variabilities of Human Adenovirus ...
WebWe recently characterized the domains of the human cofactor protein CD46 involved in binding species B2 adenovirus (Ad) serotype 35. Here, the CD46 binding determinants are mapped for the species B1 Ad serotypes 3 and 7 and for the species B2 Ad11. Ad3, 7 and 11 bound and transduced CD46-positive rodent BHK cells at levels similar to Ad35. WebB1 human adenovirus type 3 E3-9K during A549 cell line infection Kathryn M Frietze1,3, Samuel K Campos2 and Adriana E Kajon1* Abstract Background: Subspecies B1 human adenoviruses (HAdV-B1) are prevalent respiratory pathogens. Compared to their species C (HAdV-C) counterparts, relatively little work has been devoted to the characterization of ... WebJul 12, 2024 · Human adenoviruses (Ads) are classified into seven species termed A-G. Most species use the coxsackie-adenovirus receptor (CAR) as a primary cellular … in which year constitution was adopted