WebTwo AMD clinical trials (Oaks and Derby) are being launched for the development of … WebSep 10, 2024 · This now looks less likely to work out. Data from the twin Derby and Oaks trials, in a total of 1,258 patients with geographic atrophy, an advanced form of dry age-related macular degeneration, had been hotly awaited. This intravitreal form of pegcetacoplan has forecast 2026 sales of $1.2bn, according to Evaluate Pharma ’s …
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Apellis Announces Detailed Results from Phase 3 DERBY and OAKS …
WebOct 11, 2024 · Combined investigator-determined exudative AMD rates in the OAKS and DERBY studies were 6.0% in the monthly administration group, 4.1% in the every-other-month administration group, and 2.4% in the sham group. The respective results that included the reading center-detected cases not reported by investigators were 6.4%, … WebOct 4, 2024 · Twenty-four month data from the DERBY and OAKS studies better indicate the overall safety of pegcetacoplan for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Pegcetacoplan is an investigational, targeted C3 therapy, studied in over 1200 patients between the two phase 3 studies. The safety data were … WebMar 31, 2024 · In March 2024, Apellis shared 18-month data from the Phase 3 DERBY and OAKS studies with intravitreal pegcetacoplan demonstrating continuous and clinically meaningful reductions in GA lesion growth and a favorable safety profile. All nominal p-values were below 0.05 across treatment arms in both DERBY and OAKS. park county code red