WebBis(2-oxo-3-oxazolidinyl)phosphinic chloride. Molecular Weight: 254.6. BOP-Cl is a highly effective reagent for the acylation of N-methyl amino acids. It provides good yields with … WebA synthesis of Z-Thr1 -D-Abu2 -Pro3 -MePhe4 -MeA2bu(γPht)5 -Phg6 - (A2bu = α, γ-diaminobutyric acid) is reported using the very efficient coupling agent BOP-Cl (N, N'-bis(3-oxo-2-oxazolidinyl)phosphinic chloride) for imino acid peptide bond formation. The total yield is 11% for the 5 coupling steps and one lactonization. The final step was a …

Development of a new synthetic method for oligodeoxynucleotides using 3 ...

WebProduct Description: Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Cat No. : 310060000; 310060050 Synonyms BOP-Cl CAS-No 68641-49-6 Molecular Formula C6 H8 Cl N2 O5 P 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Uses advised against No Information … WebAnalytically pure dipeptides containing two iminoacids [Pro, MeAla, MePhe, MeVal and SPip (γ‐thiapipecolinic acid)] were prepared with BOP‐Cl [N,N]‐bis(2‐oxo‐3‐oxazolidinyl) … cipratan in english

BOP-CL C6H8ClN2O5P ChemSpider

Web2. The compound, salt or solvate according to claim 1, wherein in the general formula (1), Ar is a monocyclic, polycyclic, or condensed cyclic aromatic heterocyclic group comprising 5-7 membered aromatic heterocyclic ring having one or more of heteroatom(s) selected from the group consisting of nitrogen, oxygen and sulfur in at least one ring, and may have … WebDec 15, 2024 · Bis(2-oxo-3-oxazolidinyl) phosphinic chloride (Bop-Cl) (0.51 g, 2.0 mmol, 2.0 equiv) was added at 0 °C, and the mixture was stirred for 1 h at 0 °C. The mixture was warmed to rt and diluted with CH 2 Cl 2 (30 mL) and washed with 1 M triethylammonium bicarbonate (TEAB) buffers (pH 7) (3 × 30 mL). WebDescription. BOP-Cl Bis- (2-oxo-3-oxazolidinyl)phosphinic chloride or Phosphoric acid bis (2-oxooxazolidide) chlorides is widely used in solid phase peptide synthesis (SPPS). It is extremely effective reagent at cyclizing linear peptides. BOP-Cl can also be used in the coupling of acids to N-methyl amino acids. cipr east stowmarket